Irf5 interferon regulatory factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irf5provided by MGI
Official Full Name: interferon regulatory factor 5provided by MGI
Primary source: MGI:MGI:1350924
See related: Ensembl:ENSMUSG00000029771 AllianceGenome:MGI:1350924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mirf5
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein kinase binding activity. Involved in cytokine-mediated signaling pathway; defense response to symbiont; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; ovary; and urinary system. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 49.4), mammary gland adult (RPKM 16.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.36 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (29526129..29541874)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (29526130..29541869)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology.
Title: Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology.
The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Title: The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection.
Title: The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection.
Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
Title: Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis.
Title: microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis.
Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.
Title: Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.
Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Title: Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(-/-) mice.
Title: Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(-/-) mice.
One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis.
Title: One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis.
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Title: Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in response to peptidoglycan	IEA Inferred from Electronic Annotation more info
involved_in response to peptidoglycan	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon regulatory factor 5

Names: interferon regulatory factor 5 bone marrow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252382.1 → NP_001239311.1 interferon regulatory factor 5 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AC079276, AF028725, AW491843, BY749804

UniProtKB/Swiss-Prot

P56477

Conserved Domains (2) summary

pfam00605
Location:25 → 130

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:256 → 439

IRF-3; Interferon-regulatory factor 3
NM_001311083.1 → NP_001298012.1 interferon regulatory factor 5 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the UTRs and 5' and 3' coding regions and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AK171356, BY749561

Consensus CDS

CCDS80504.1

UniProtKB/TrEMBL

F6Z6C6

Related

ENSMUSP00000126273.3, ENSMUST00000167252.5

Conserved Domains (2) summary

pfam00605
Location:16 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:247 → 430

IRF-3; Interferon-regulatory factor 3
NM_012057.4 → NP_036187.1 interferon regulatory factor 5 isoform 2

See identical proteins and their annotated locations for NP_036187.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different 5' end, which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and different N-terminus when it is compared to isoform 1.

Source sequence(s)

AF028725, AW491843, BY749561

Consensus CDS

CCDS19962.1

UniProtKB/Swiss-Prot

P56477

UniProtKB/TrEMBL

B2CC69, Q3U169

Related

ENSMUSP00000004392.6, ENSMUST00000004392.12

Conserved Domains (2) summary

pfam00605
Location:16 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:247 → 430

IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

29526129..29541874

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505095.2 → XP_006505158.1 interferon regulatory factor 5 isoform X1

Conserved Domains (2) summary

pfam00605
Location:43 → 148

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:274 → 457

IRF-3; Interferon-regulatory factor 3
XM_006505098.2 → XP_006505161.1 interferon regulatory factor 5 isoform X4

See identical proteins and their annotated locations for XP_006505161.1

Conserved Domains (1) summary

pfam10401
Location:179 → 362

IRF-3; Interferon-regulatory factor 3
XM_030255430.2 → XP_030111290.1 interferon regulatory factor 5 isoform X2

Conserved Domains (2) summary

pfam00605
Location:26 → 131

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:257 → 440

IRF-3; Interferon-regulatory factor 3
XM_006505097.3 → XP_006505160.1 interferon regulatory factor 5 isoform X3

See identical proteins and their annotated locations for XP_006505160.1

UniProtKB/Swiss-Prot

P56477

UniProtKB/TrEMBL

B2CC69, Q3U169

Conserved Domains (2) summary

pfam00605
Location:16 → 121

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:247 → 430

IRF-3; Interferon-regulatory factor 3
XM_006505100.4 → XP_006505163.1 interferon regulatory factor 5 isoform X4

See identical proteins and their annotated locations for XP_006505163.1

Conserved Domains (1) summary

pfam10401
Location:179 → 362

IRF-3; Interferon-regulatory factor 3
XM_006505099.5 → XP_006505162.1 interferon regulatory factor 5 isoform X4

See identical proteins and their annotated locations for XP_006505162.1

Conserved Domains (1) summary

pfam10401
Location:179 → 362

IRF-3; Interferon-regulatory factor 3