ptf1a pancreas associated transcription factor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptf1aprovided by ZNC
Official Full Name: pancreas associated transcription factor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-579
See related: Ensembl:ENSDARG00000014479 AllianceGenome:ZFIN:ZDB-GENE-030616-579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PTF1; zgc:112216; si:zc142h2.2
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including exocrine pancreas development; neuron differentiation; and positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including exocrine cell; intestinal bulb primordium; mid intestine; nervous system; and pancreatic system. Human ortholog(s) of this gene implicated in pancreatic agenesis 1. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (29710770..29712071)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (29727237..29728538)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
Title: Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
Results highlight the possibility that Ptf1a may act as an important transcription factor for enteric neuron development.
Title: A novel subset of enteric neurons revealed by ptf1a:GFP in the developing zebrafish enteric nervous system.
In ptf1a haploinsufficiency, more ptf1a-lineage-labeled cells are traced into the pancreatic Notch-responsive cell and endocrine compartments. More reduction of ptf1a gene dosage converts pancreatic progenitor cells to non-pancreatic cell fates.
Title: Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.
Autoregulation of ptf1a is absolutely required for exocrine pancreas formation.
Title: Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish.
Postembryonic antagonism of Ptf1a, a master regulator of pancreatic development and acinar cell fate specification, induced expression of endocrine genes including insulin in the exocrine compartment. Induced insulin+ cells are derived from acinar cells.
Title: Suppression of Ptf1a activity induces acinar-to-endocrine conversion.
The timing of Ptf1a expression suggests that it is involved in the very early stages or steps in the differentiation of amacrine cells, which can be seen to rapidly diversify into a large number of subtypes.
Title: Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina.
Exocrine differentiation and proliferation factor (exdpf) is a direct target gene of pancreas-specific transcription factor 1a (Ptf1a).
Title: Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish.
We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate.
Title: Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.
mapping, analysis of embryonic expression and role in pancreas development
Title: Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates.
Ptf1 function is inhibited by notch
Title: Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within amacrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocrine pancreas development	ISS Inferred from Sequence or Structural Similarity more info
involved_in generation of neurons	ISS Inferred from Sequence or Structural Similarity more info
involved_in hindbrain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pancreas transcription factor 1 subunit alpha

Names: Ptfa; bHLH transcription factor p48; pancreas specific transcription factor, 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207641.2 → NP_997524.1 pancreas transcription factor 1 subunit alpha

See identical proteins and their annotated locations for NP_997524.1

Status: PROVISIONAL

Source sequence(s)

BC093269

UniProtKB/Swiss-Prot

Q7ZSX3

Related

ENSDARP00000011265.4, ENSDART00000021987.6

Conserved Domains (1) summary

cd11417
Location:117 → 171

bHLH_TS_PTF1A; basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins