socs3b suppressor of cytokine signaling 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: socs3bprovided by ZNC
Official Full Name: suppressor of cytokine signaling 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2528
See related: Ensembl:ENSDARG00000026611 AllianceGenome:ZFIN:ZDB-GENE-040426-2528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77038
Summary: Predicted to enable cytokine receptor binding activity. Acts upstream of or within brain development. Is expressed in eye; heart; lateral line ganglion; and segmental plate. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (34273346..34277465)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (34172283..34176402)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Socs3b regulates the development and function of innate immune cells in zebrafish.
Title: Socs3b regulates the development and function of innate immune cells in zebrafish.
Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA.
Title: Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213304.1 → NP_998469.1 suppressor of cytokine signaling 3b

See identical proteins and their annotated locations for NP_998469.1

Status: PROVISIONAL

Source sequence(s)

BC066573

UniProtKB/TrEMBL

F6PAN6, L0N8W0, Q6NYJ2

Related

ENSDARP00000096314.3, ENSDART00000037904.7

Conserved Domains (2) summary

cd10384
Location:40 → 140

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:169 → 210

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...