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    nck2a NCK adaptor protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nck2aprovided by ZNC
    Official Full Name
    NCK adaptor protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-686
    See related
    Ensembl:ENSDARG00000018206 AllianceGenome:ZFIN:ZDB-GENE-040426-686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Nck2; zgc:55283
    Summary
    Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; positive regulation of translation in response to endoplasmic reticulum stress; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in cytoplasm. Is expressed in rhombomere 3 and rhombomere 5. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nck2a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6395137..6502102, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6417152..6524194, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene ECRG4 augurin precursor a Neighboring gene uncharacterized LOC137496441 Neighboring gene four and a half LIM domains 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. Li J, et al. Sci Total Environ, 2022 Aug 25. PMID 35525365
    2. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169
    3. Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. Zhang J, et al. FASEB J, 2023 May. PMID 37086087
    4. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
    5. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55283

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of PERK-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200997.1 → NP_957291.1  cytoplasmic protein NCK2a

      See identical proteins and their annotated locations for NP_957291.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046872
      UniProtKB/TrEMBL
      Q803A2
      Related
      ENSDARP00000093447.3, ENSDART00000102672.6
      Conserved Domains (4) summary
      cd10409
      Location:306 → 403
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11766
      Location:122 → 174
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:217 → 275
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      6395137..6502102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223351.1 → XP_068079452.1  cytoplasmic protein NCK2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4I8, F1R1C3

    2. XM_009304471.4 → XP_009302746.1  cytoplasmic protein NCK2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4I8, F1R1C3
      Conserved Domains (4) summary
      cd10409
      Location:306 → 403
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11766
      Location:122 → 174
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:217 → 275
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_068223352.1 → XP_068079453.1  cytoplasmic protein NCK2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4I8, F1R1C3
    Nucleotide Protein Strain
    Heading Accession and Version

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