furina furin (paired basic amino acid cleaving enzyme) a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: furinaprovided by ZNC
Official Full Name: furin (paired basic amino acid cleaving enzyme) aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040901-1
See related: Ensembl:ENSDARG00000062909 AllianceGenome:ZFIN:ZDB-GENE-040901-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: furin; si:dkey-281a24.5
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fin morphogenesis; left/right pattern formation; and skeletal system development. Predicted to be located in membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; liver; median fin fold; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (13996024..14203393)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (13750304..13961894)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.
Title: Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.
Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway.
Title: Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway.
Proprotein convertase furina is required for heart development in zebrafish.
Title: Proprotein convertase furina is required for heart development in zebrafish.
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Title: The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
Title: Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube left/right pattern formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: furin (paired basic amino acid cleaving enzyme) a

Names: ace of hearts; aoh; stu; sturgeon; unm_hu119

NP_001038571.1

EC 3.4.21.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045106.2 → NP_001038571.1 furin (paired basic amino acid cleaving enzyme) a precursor

See identical proteins and their annotated locations for NP_001038571.1

Status: PROVISIONAL

Source sequence(s)

BC139879

UniProtKB/TrEMBL

A0A8M3ATW6, F1QQ43, Q1KHF9

Related

ENSDARP00000085903.6, ENSDART00000091470.7

Conserved Domains (5) summary

cd04059
Location:113 → 401

Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases

smart00261
Location:645 → 682

FU; Furin-like repeats

pfam00082
Location:144 → 427

Peptidase_S8; Subtilase family

pfam01483
Location:484 → 570

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain