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    ing5b inhibitor of growth family, member 5b [ Danio rerio (zebrafish) ]

    Gene ID: 368450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ing5bprovided by ZNC
    Official Full Name
    inhibitor of growth family, member 5bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-462
    See related
    Ensembl:ENSDARG00000068175 AllianceGenome:ZFIN:ZDB-GENE-030616-462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    p33; ING1; wu:fc94a02; zgc:100910; si:dz40g1.1; si:busm1-40g1.1
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in positive regulation of apoptotic signaling pathway and regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Orthologous to human ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ing5b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (36606006..36608661)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (36623549..36626303)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha variable 5-like Neighboring gene uncharacterized LOC101886155 Neighboring gene p21 protein (Cdc42/Rac)-activated kinase 2a Neighboring gene kelch-like family member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic variation in the pattern of gene paralog retention between the teleost superorders Ostariophysi and Acanthopterygii. Garcia de la Serrana D, et al. Genome Biol Evol, 2014 Apr. PMID 24732281, Free PMC Article
    2. Phylogenetic analysis of the ING family of PHD finger proteins. He GH, et al. Mol Biol Evol, 2005 Jan. PMID 15356280
    3. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Buchner DA, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17715297, Free PMC Article
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 5b
    Names
    tumor suppressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007168.1 → NP_001007169.1  inhibitor of growth protein 5b

      See identical proteins and their annotated locations for NP_001007169.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079501
      UniProtKB/TrEMBL
      Q6AXK3
      Related
      ENSDARP00000089186.2, ENSDART00000098415.4
      Conserved Domains (3) summary
      COG5034
      Location:7 → 232
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15586
      Location:188 → 232
      PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
      pfam12998
      Location:6 → 105
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      36606006..36608661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171273.5 → XP_005171330.1  inhibitor of growth protein 5b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIJ2
      Conserved Domains (3) summary
      COG5034
      Location:7 → 231
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15586
      Location:187 → 231
      PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
      pfam12998
      Location:6 → 105
      ING; Inhibitor of growth proteins N-terminal histone-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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