cmlc1 cardiac myosin light chain-1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cmlc1provided by ZNC
Official Full Name: cardiac myosin light chain-1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030522-1
See related: Ensembl:ENSDARG00000032976 AllianceGenome:ZFIN:ZDB-GENE-030522-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103441
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within heart contraction; heart morphogenesis; and myofibril assembly. Predicted to be part of myosin II complex. Is expressed in cardiac muscle myoblast; heart primordium; mesoderm; pericardial region; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (64167616..64168415, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (63486421..63487216, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using adult heterozygous zebrafish, show that ELC S195 phosphorylation is pivotal for adaptation of cardiac function to augmented physical stress and provide novel mechanistic insights into the pathogenesis of ELC-linked cardiomyopathy.
Title: Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.
A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.
Title: A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.
There are distinct roles for cmlc1 and cmlc2 during zebrafish cardiogenesis.
Title: Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cardiac myosin light chain-1

Names: laz; lazy susan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131692.2 → NP_571767.2 cardiac myosin light chain-1

Status: VALIDATED

Source sequence(s)

AL845516

UniProtKB/TrEMBL

A0A8N7UZM3, Q5XJC3

Related

ENSDARP00000048394.2, ENSDART00000048395.3

Conserved Domains (1) summary

cl25352
Location:48 → 195

EFh_PEF; The penta-EF hand (PEF) family