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    • Showing Current items.

    oclna occludin a [ Danio rerio (zebrafish) ]

    Gene ID: 405757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oclnaprovided by ZNC
    Official Full Name
    occludin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2685
    See related
    Ensembl:ENSDARG00000005108 AllianceGenome:ZFIN:ZDB-GENE-040426-2685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ocln; zgc:56359; wu:fd23h10; wu:fi13c01; zgc:113992
    Summary
    Predicted to be involved in bicellular tight junction assembly. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including EVL; digestive system; musculature system; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See oclna in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2924775..2942926, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2897604..2915755, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene endoplasmic reticulum aminopeptidase 1a Neighboring gene MARVEL domain containing 2a Neighboring gene uncharacterized LOC137496551 Neighboring gene zinc finger, FYVE domain containing 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cortisol regulates epithelial permeability and sodium losses in zebrafish exposed to acidic water. Kwong RW, et al. J Endocrinol, 2013 Jun. PMID 23503775
    2. Genetic control of single lumen formation in the zebrafish gut. Bagnat M, et al. Nat Cell Biol, 2007 Aug. PMID 17632505
    3. Bacterial induction of Snail1 contributes to blood-brain barrier disruption. Kim BJ, et al. J Clin Invest, 2015 Jun. PMID 25961453, Free PMC Article
    4. Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio). Jia J, et al. Biochem Biophys Res Commun, 2018 May 5. PMID 29574160
    5. Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Chen Z, et al. Front Microbiol, 2020. PMID 32670209, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56359, MGC113992

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    occludin
    NP_997997.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212832.2 → NP_997997.2  occludin

      Status: VALIDATED

      Source sequence(s)
      CR394525
      UniProtKB/TrEMBL
      A0A8M1PI39, F1R799
      Related
      ENSDARP00000010183.6, ENSDART00000002622.7
      Conserved Domains (2) summary
      pfam01284
      Location:40 → 217
      MARVEL; Membrane-associating domain
      pfam07303
      Location:393 → 488
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      2924775..2942926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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