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    eif4h eukaryotic translation initiation factor 4h [ Danio rerio (zebrafish) ]

    Gene ID: 402996, updated on 4-Jan-2025

    Summary

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    Official Symbol
    eif4hprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4hprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010328-19
    See related
    Ensembl:ENSDARG00000042252 AllianceGenome:ZFIN:ZDB-GENE-010328-19
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wbscr1; zgc:77282
    Summary
    Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to act upstream of or within translational initiation. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See eif4h in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (4585401..4616816, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (4594254..4625669, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487714 Neighboring gene transcription factor Dp-2 Neighboring gene uncharacterized LOC103908797 Neighboring gene ring finger and FYVE-like domain containing E3 ubiquitin protein ligase Neighboring gene si:dkey-35i13.1 Neighboring gene uncharacterized LOC137487715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression and phylogeny of claudins in vertebrate primordia. Kollmar R, et al. Proc Natl Acad Sci U S A, 2001 Aug 28. PMID 11517306, Free PMC Article
    2. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
    3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77282

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4H
    Names
    Williams-Beuren syndrome chromosome region 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197328.1 → NP_001184257.1  eukaryotic translation initiation factor 4H isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CT962513, EH515860, EH552521, FP141411
      UniProtKB/TrEMBL
      A0A0R4IG09, A0A8M1NUW6
      Related
      ENSDARP00000131876.2, ENSDART00000160191.2
      Conserved Domains (2) summary
      COG0724
      Location:39 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12401
      Location:43 → 118
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

    2. NM_001197329.1 → NP_001184258.1  eukaryotic translation initiation factor 4H isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CT633866, CT962513
      UniProtKB/TrEMBL
      A0A0R4ICV9, A0A8M1NXE7
      Related
      ENSDARP00000130536.1, ENSDART00000161721.2
      Conserved Domains (2) summary
      COG0724
      Location:39 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12401
      Location:43 → 118
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

    3. NM_205695.2 → NP_991258.2  eukaryotic translation initiation factor 4H isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CT962513, EH515860, EH552521
      UniProtKB/TrEMBL
      A0A8M1PK31, F1QYM4
      Related
      ENSDARP00000117924.2, ENSDART00000144949.4
      Conserved Domains (2) summary
      COG0724
      Location:39 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12401
      Location:43 → 118
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      4585401..4616816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291449.4 → XP_009289724.1  eukaryotic translation initiation factor 4H isoform X1

      UniProtKB/TrEMBL
      A0A8M3AI90
      Conserved Domains (2) summary
      COG0724
      Location:39 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12401
      Location:43 → 118
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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