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    ctdnep1a CTD nuclear envelope phosphatase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 492343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctdnep1aprovided by ZNC
    Official Full Name
    CTD nuclear envelope phosphatase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-177
    See related
    Ensembl:ENSDARG00000016519 AllianceGenome:ZFIN:ZDB-GENE-041114-177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dullard; fi48e07; zgc:92207; im:7137489; wu:fi48e07
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in nuclear envelope organization; positive regulation of triglyceride biosynthetic process; and protein dephosphorylation. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ctdnep1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24047258..24056796)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23543509..23552996)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase a, polypeptide 3a Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1a Neighboring gene GABA(A) receptor-associated protein a Neighboring gene G protein pathway suppressor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Okuda Y, et al. Dev Dyn, 2006 Mar. PMID 16408288
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear envelope organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTD nuclear envelope phosphatase 1A
    Names
    ctdnep1
    dullard homolog
    serine/threonine-protein phosphatase dullard-A
    NP_001007310.1
    XP_021331802.1
    XP_068077264.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007309.1 → NP_001007310.1  CTD nuclear envelope phosphatase 1A

      See identical proteins and their annotated locations for NP_001007310.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085649
      UniProtKB/Swiss-Prot
      Q5U395, Q5U3T3
      UniProtKB/TrEMBL
      A0A8M9PK13
      Related
      ENSDARP00000036009.5, ENSDART00000029889.6
      Conserved Domains (1) summary
      TIGR02251
      Location:62 → 230
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      24047258..24056796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221163.1 → XP_068077264.1  CTD nuclear envelope phosphatase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q5U395, Q5U3T3
      UniProtKB/TrEMBL
      A0A8M9PK13

    2. XM_021476127.2 → XP_021331802.1  CTD nuclear envelope phosphatase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q5U395, Q5U3T3
      UniProtKB/TrEMBL
      A0A8M9PK13
      Conserved Domains (1) summary
      TIGR02251
      Location:62 → 230
      HIF-SF_euk; Dullard-like phosphatase domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394575.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      53040..62527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U395.1 GenPept UniProtKB/Swiss-Prot:Q5U395

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