csnk1e casein kinase 1, epsilon [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: csnk1eprovided by ZNC
Official Full Name: casein kinase 1, epsilonprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7873
See related: Ensembl:ENSDARG00000045150 AllianceGenome:ZFIN:ZDB-GENE-030131-7873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj38c01; zgc:77310; wu:fj38c01; wu:fj62a04
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; eye; notochord; and otic vesicle. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to several human genes including CSNK1E (casein kinase 1 epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (19305488..19318374)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (19183614..19196500)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj62a04.x1 (e-PCR)
- UniSTS:199686

fj38c01.x1 (e-PCR)
- UniSTS:199253

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: casein kinase I

Names: casein kinase I, epsilon

NP_997912.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212747.1 → NP_997912.1 casein kinase I

See identical proteins and their annotated locations for NP_997912.1

Status: PROVISIONAL

Source sequence(s)

BC065339

UniProtKB/TrEMBL

A8CYV5, F6NLU0, Q6P109

Related

ENSDARP00000066390.4, ENSDART00000066391.5

Conserved Domains (2) summary

COG0515
Location:8 → 360

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon