pmchl pro-melanin-concentrating hormone, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pmchlprovided by ZNC
Official Full Name: pro-melanin-concentrating hormone, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7863
See related: Ensembl:ENSDARG00000076978 AllianceGenome:ZFIN:ZDB-GENE-030131-7863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Pmch1; fj37c10; wu:fj37c10
Summary: Predicted to enable type 1 melanin-concentrating hormone receptor binding activity. Predicted to be involved in negative regulation of dopaminergic synaptic transmission. Predicted to act upstream of or within chemical synaptic transmission. Is expressed in female organism; male organism; and nervous system. Orthologous to human PMCH (pro-melanin concentrating hormone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (54685175..54685710)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (54042495..54043030)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The evolution of pomc, pmch and pmchl genes and acquisition of hormonal status for MCHL explain different mechanisms used by vertebrates to background-adapt
Title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.
Zebrafish Pmch genes are expressed in closely associated but non-overlapping neurons within the hypothalamus, and pmch2-expressing neurons send numerous projections to multiple MCH receptor-rich targets. [pmch2]
Title: Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system.
Zebrafish Pmch genes are expressed in closely associated but non-overlapping neurons within the hypothalamus. Pmch1 expression correlate with pigmentation changes.
Title: Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables melanin-concentrating hormone activity	IEA Inferred from Electronic Annotation more info
enables type 1 melanin-concentrating hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, dopaminergic	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: pro-melanin-concentrating hormone, like

Names: pro-melanin concentrating hormone-like protein; pro-melanin-concentrating hormone 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.