dact2 dishevelled-binding antagonist of beta-catenin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dact2provided by ZNC
Official Full Name: dishevelled-binding antagonist of beta-catenin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9975
See related: Ensembl:ENSDARG00000056986 AllianceGenome:ZFIN:ZDB-GENE-030131-9975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Amin; dact; dpr2; frd2; frodo2; dapper2; wu:fe24f12; zgc:109729; zgc:152832; ik:tdsubc_1d9; xx:tdsubc_1d9
Summary: Involved in negative regulation of nodal signaling pathway. Acts upstream of or within Wnt signaling pathway and mesoderm morphogenesis. Predicted to be located in late endosome; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including blastodisc; brain; digestive system; germ ring; and mesoderm. Used to study bile duct carcinoma; pancreatic carcinoma; and retinitis pigmentosa. Orthologous to human DACT2 (dishevelled binding antagonist of beta catenin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (43400400..43407199)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (43266575..43273374)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dact2 is involved in the regulation of epithelial-mesenchymal transition.
Title: Dact2 is involved in the regulation of epithelial-mesenchymal transition.
target of beta-catenin and/or an unknown downstream effector in development
Title: Regulation of the early expression patterns of the zebrafish Dishevelled-interacting proteins Dapper1 and Dapper2.
expressed in mesoderm precursors during early embryogenesis and is positively regulated by Nodal signals
Title: Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.
frd2 is expressed in the developing brain and mesoderm.
Title: Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish.
two Dvl-associated paralogs, Dpr1 and Dpr2, participate in distinct Wnt-dependent developmental processes
Title: Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nodal signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of nodal signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dapper homolog 2

Names: antagonist of mesoderm induction by nodal; dapper 2; dapper homolog 2, antagonist of beta-catenin; dishevelled-interacting protein; frodo 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.