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    gtpbp1l GTP binding protein 1, like [ Danio rerio (zebrafish) ]

    Gene ID: 402863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtpbp1lprovided by ZNC
    Official Full Name
    GTP binding protein 1, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041007-2
    See related
    Ensembl:ENSDARG00000042900 AllianceGenome:ZFIN:ZDB-GENE-041007-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Is expressed in several structures, including brain; eye; immature eye; mesoderm; and vasculature. Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gtpbp1l in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (14836235..14851695)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (14811658..14827142)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 1Ba Neighboring gene uncharacterized LOC110438273 Neighboring gene uncharacterized LOC100537797 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2a Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. GTP-Binding Protein 1-Like (GTPBP1l) Regulates Vascular Patterning during Zebrafish Development. Lo YH, et al. Biomedicines, 2022 Dec 10. PMID 36551964, Free PMC Article
    2. Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. Gangras P, et al. PLoS Genet, 2020 Jun. PMID 32502192, Free PMC Article
    3. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Li RF, et al. Biomedicines, 2022 May 27. PMID 35740282, Free PMC Article
    4. Identification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish. Emerson SE, et al. Dev Dyn, 2017 Jul. PMID 28440030, Free PMC Article
    5. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP binding protein 1, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024811.1 → NP_001019982.1  GTP binding protein 1, like

      See identical proteins and their annotated locations for NP_001019982.1

      Status: VALIDATED

      Source sequence(s)
      BC096803
      UniProtKB/TrEMBL
      A0A8M3AMX4, A3KQI1, Q4V9N2
      Related
      ENSDARP00000105786.2, ENSDART00000122740.3
      Conserved Domains (4) summary
      cd04165
      Location:154 → 378
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:70 → 566
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:387 → 473
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:479 → 565
      GTPBP_III; Domain III of the GP-1 family of GTPases

    2. NM_001430984.1 → NP_001417913.1  GTP binding protein 1, like

      Status: VALIDATED

      Source sequence(s)
      BX649639
      UniProtKB/TrEMBL
      A0A8M3AMX4, A3KQI1
      Related
      ENSDARP00000155870.1, ENSDART00000180951.1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      14836235..14851695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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