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    atat1 alpha tubulin acetyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atat1provided by ZNC
    Official Full Name
    alpha tubulin acetyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2120
    See related
    Ensembl:ENSDARG00000004472 AllianceGenome:ZFIN:ZDB-GENE-040426-2120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TAT; mec17; zgc:65893; zgc:77443; wu:fj19c03
    Summary
    Enables tubulin N-acetyltransferase activity. Acts upstream of or within alpha-tubulin acetylation. Predicted to be located in several cellular components, including clathrin-coated pit; focal adhesion; and microtubule cytoskeleton. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atat1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (27479590..27515979)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27895367..27931428)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch73-25f10.6 Neighboring gene si:ch211-152p11.8 Neighboring gene small nucleolar RNA SNORD52 Neighboring gene si:ch211-152p11.4 Neighboring gene si:dkeyp-46h3.8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus. Kormendi V, et al. J Biol Chem, 2012 Dec 7. PMID 23105108, Free PMC Article
    2. Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Łysyganicz PK, et al. Front Cell Dev Biol, 2021. PMID 34268305, Free PMC Article
    3. Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. Theisen U, et al. J Cell Biol, 2020 Oct 5. PMID 32668451, Free PMC Article
    4. MEC-17 is an alpha-tubulin acetyltransferase. Akella JS, et al. Nature, 2010 Sep 9. PMID 20829795, Free PMC Article
    5. Zebrafish Chromosome 14 Gene Differential Expression in the fmr1 (h u2787) Model of Fragile X Syndrome. Barthelson K, et al. Front Genet, 2021. PMID 34135935, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
      Title: Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tubulin N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alpha-tubulin acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alpha-tubulin acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within alpha-tubulin acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in alpha-tubulin acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-tubulin N-acetyltransferase 1
    Names
    MEChanosensory abnormality homolog
    NP_001315192.1
    NP_001315193.1
    NP_998423.1
    XP_005170075.1
    XP_005170077.1
    XP_009292483.1
    XP_009292484.1
    XP_017207708.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328263.1 → NP_001315192.1  alpha-tubulin N-acetyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC056749, FP101887
      UniProtKB/Swiss-Prot
      Q6NZT0, Q6PH17
      UniProtKB/TrEMBL
      A0A8M2BHB3
      Related
      ENSDARP00000094698.4, ENSDART00000103922.5
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    2. NM_001328264.1 → NP_001315193.1  alpha-tubulin N-acetyltransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC065981, FP101887
      UniProtKB/TrEMBL
      A0A2R8QNV1
      Related
      ENSDARP00000154756.1, ENSDART00000185426.1
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    3. NM_213258.2 → NP_998423.1  alpha-tubulin N-acetyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_998423.1

      Status: VALIDATED

      Source sequence(s)
      BC065981, FP101887
      UniProtKB/Swiss-Prot
      Q6PH17
      Related
      ENSDARP00000049367.5, ENSDART00000049368.7
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      27479590..27515979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294209.4 → XP_009292484.1  alpha-tubulin N-acetyltransferase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AKY5
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    2. XM_009294208.4 → XP_009292483.1  alpha-tubulin N-acetyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B3H4
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    3. XM_005170018.5 → XP_005170075.1  alpha-tubulin N-acetyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHR9
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    4. XM_005170020.5 → XP_005170077.1  alpha-tubulin N-acetyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHA8
      Conserved Domains (1) summary
      pfam05301
      Location:74 → 185
      Mec-17; Touch receptor neuron protein Mec-17

    5. XM_017352219.3 → XP_017207708.1  alpha-tubulin N-acetyltransferase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z2Y2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PH17.1 GenPept UniProtKB/Swiss-Prot:Q6PH17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.