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    rab28 RAB28, member RAS oncogene family [ Danio rerio (zebrafish) ]

    Gene ID: 326923, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rab28provided by ZNC
    Official Full Name
    RAB28, member RAS oncogene familyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5122
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-5122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55578; wu:fe49e06
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within phagocytosis; regulation of phagosome maturation; and vitamin A metabolic process. Predicted to be located in cytoplasm. Predicted to be active in Golgi apparatus and endosome. Is expressed in cranial nerve II; pharyngeal arch 3-7 skeleton; retina; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See rab28 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003336300.2 (408..1269)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336300.2 (408..1269)

    NW_003336300.2Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene therapy for RAB28: What can we learn from zebrafish? Moran AL, et al. Vision Res, 2023 Sep. PMID 37321111
    2. Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration. Carter SP, et al. Front Cell Dev Biol, 2020. PMID 32258030, Free PMC Article
    3. Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28. Moran AL, et al. FASEB J, 2022 May. PMID 35471581, Free PMC Article
    4. A plasmid library of full-length zebrafish rab proteins for in vivo cell biology. Hall TE, et al. Cell Logist, 2017. PMID 28396820, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin A metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-28
    NP_956046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199752.1 → NP_956046.1  ras-related protein Rab-28

      See identical proteins and their annotated locations for NP_956046.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045389
      UniProtKB/TrEMBL
      Q7ZVW0
      Conserved Domains (2) summary
      smart00175
      Location:13 → 178
      RAB; Rab subfamily of small GTPases
      cd04109
      Location:13 → 221
      Rab28; Rab GTPase family 28 (Rab28)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NW_003336300.2 Reference GRCz11 Primary Assembly

      Range
      408..1269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials