septin7b septin 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: septin7bprovided by ZNC
Official Full Name: septin 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-37
See related: Ensembl:ENSDARG00000052673 AllianceGenome:ZFIN:ZDB-GENE-030131-37
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sept7b; fj67f02; zeh0351; hm:zeh0351; wu:fj67f02
Summary: Predicted to enable GTPase activity and molecular adaptor activity. Acts upstream of or within defense response to bacterium. Predicted to be located in cilium and kinetochore. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (47390275..47426482, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (47455189..47491470, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that sept7b expression is conserved in the developing vertebrate pancreas, and that the multipotent pancreatic progenitors of the larval zebrafish do not reach the mature state upon knockdown of sept7b. The data indicate that sept7b is essential for the specification and differentiation of the endocrine cell types and that sept7b affects endocrine differentiation by modulating the Notch-pathway.
Title: sept7b is required for the differentiation of pancreatic endocrine progenitors.
Knockdown of the zebrafish ortholog of human septin 7 (sept7b) destabilizes cardiac actin and reduces ventricular dimensions, contractility, and cardiac output in larval zebrafish, indicating that sept7b is essential for cardiac function. We further found that sept7b and retinoic acid signaling pathways converge to regulate cardiac function.
Title: Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IEA Inferred from Electronic Annotation more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: septin 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256029.1 → NP_001242958.1 septin 7b

Status: PROVISIONAL

Source sequence(s)

BC097235

UniProtKB/TrEMBL

A0A8M1NZC4, A0A8M2B4V3

Related

ENSDARP00000125075.1, ENSDART00000148631.3

Conserved Domains (2) summary

cd01850
Location:26 → 296

CDC_Septin; CDC/Septin GTPase family

COG5019
Location:8 → 374

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

47390275..47426482 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068213827.1 → XP_068069928.1 septin 7b isoform X3

UniProtKB/TrEMBL

A0A8M3AJH4
XM_068213826.1 → XP_068069927.1 septin 7b isoform X2

UniProtKB/TrEMBL

A0A8M6Z1Q7, F8W5J3

Related

ENSDARP00000069063.5, ENSDART00000074575.5
XM_009292677.4 → XP_009290952.1 septin 7b isoform X1

UniProtKB/TrEMBL

A0A8M3AR12, A0A8M3ATV2

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

COG5019
Location:1 → 349

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]