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    sec23a Sec23 homolog A, coat complex II component [ Danio rerio (zebrafish) ]

    Gene ID: 406774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sec23aprovided by ZNC
    Official Full Name
    Sec23 homolog A, coat complex II componentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2823
    See related
    Ensembl:ENSDARG00000104230 AllianceGenome:ZFIN:ZDB-GENE-040426-2823
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55534; wu:fc10f08; wu:fi15g03
    Summary
    Predicted to enable GTPase activator activity and zinc ion binding activity. Acts upstream of or within pectoral fin morphogenesis; protein targeting; and skeletal system development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including cartilage element; hatching gland; notochord; polster; and tail bud. Used to study craniolenticulosutural dysplasia. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sec23a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (10090681..10145432)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (9934647..9989398)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zgc:109986 Neighboring gene signal recognition particle 54 Neighboring gene adenosine receptor A3 Neighboring gene uncharacterized LOC137488071 Neighboring gene C-type lectin domain containing 14A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. Cox NJ, et al. Biochemistry, 2018 Jan 9. PMID 29161034, Free PMC Article
    2. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Boyadjiev SA, et al. Nat Genet, 2006 Oct. PMID 16980979
    3. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Lang MR, et al. Nat Genet, 2006 Oct. PMID 16980978
    4. Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo. Chaudhury S, et al. Development, 2020 Sep 18. PMID 32839180
    5. The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Melville DB, et al. Dis Model Mech, 2011 Nov. PMID 21729877, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sec23b is an essential component of the cartilage extracellular matrix secretory pathway in chondrocytes
      Title: Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within COPII-coated vesicle budding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pectoral fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec23A
    Names
    SEC23-related protein A
    Sec23 homolog A, COPII coat complex component
    cru
    crusher

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213465.1 → NP_998630.1  protein transport protein Sec23A

      See identical proteins and their annotated locations for NP_998630.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052768
      UniProtKB/Swiss-Prot
      Q4V948, Q7SZE5
      UniProtKB/TrEMBL
      B2GSV7
      Related
      ENSDARP00000137308.1, ENSDART00000160156.2
      Conserved Domains (6) summary
      cd11287
      Location:610 → 730
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 763
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 388
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 96
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:522 → 615
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:401 → 504
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      10090681..10145432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SZE5.1 GenPept UniProtKB/Swiss-Prot:Q7SZE5

    Gene LinkOut

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