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    nedd1 NEDD1 gamma-tubulin ring complex targeting factor [ Danio rerio (zebrafish) ]

    Gene ID: 406827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nedd1provided by ZNC
    Official Full Name
    NEDD1 gamma-tubulin ring complex targeting factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2906
    See related
    Ensembl:ENSDARG00000013472 AllianceGenome:ZFIN:ZDB-GENE-040426-2906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb78g03; zgc:63491; wu:fb78g03
    Summary
    Predicted to enable gamma-tubulin binding activity. Acts upstream of or within protein localization to centrosome. Located in centrosome and cytoplasm. Is expressed in central nervous system; neural tube; optic cup; and solid lens vesicle. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nedd1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (19541021..19556974)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (19443070..19459023)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene glutaminase like Neighboring gene SH3-domain GRB2-like 3b Neighboring gene si:ch211-59o9.10 Neighboring gene LYR motif containing 5b Neighboring gene synaptonemal complex protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An essential function for the centrosomal protein NEDD1 in zebrafish development. Manning JA, et al. Cell Death Differ, 2010 Aug. PMID 20150915
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NEDD1
    Names
    neural precursor cell expressed, developmentally down-regulated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213506.1 → NP_998671.1  protein NEDD1

      See identical proteins and their annotated locations for NP_998671.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058053
      UniProtKB/TrEMBL
      Q6PEI2
      Conserved Domains (3) summary
      COG2319
      Location:14 → 301
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:34 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:38 → 77
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      19541021..19556974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163004.5 → XP_005163061.1  protein NEDD1 isoform X1

      See identical proteins and their annotated locations for XP_005163061.1

      UniProtKB/TrEMBL
      A0A8M2BA03, F1QAL1
      Related
      ENSDARP00000016280.8, ENSDART00000027740.8
      Conserved Domains (3) summary
      COG2319
      Location:14 → 301
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:34 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:38 → 77
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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