U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nr2f6a nuclear receptor subfamily 2, group F, member 6a [ Danio rerio (zebrafish) ]

    Gene ID: 325637, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nr2f6aprovided by ZNC
    Official Full Name
    nuclear receptor subfamily 2, group F, member 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4362
    See related
    Ensembl:ENSDARG00000003607 AllianceGenome:ZFIN:ZDB-GENE-030131-4362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NR2F6; couptf2; fc94g11; COUP(II); zgc:77259; wu:fc94g11
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and nervous system development. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in brain; retina; retinal inner nuclear layer; somite; and ventricular zone. Orthologous to human NR2F6 (nuclear receptor subfamily 2 group F member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nr2f6a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24374325..24386382)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24718660..24730731)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 68 Neighboring gene plasmalemma vesicle associated protein a Neighboring gene zgc:154006 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143. Miyasaka KY, et al. Mech Dev, 2011 Jan-Feb. PMID 20869435
    2. Differentiation of arterial and venous endothelial cells and vascular morphogenesis. Hirashima M, et al. Endothelium, 2006 Mar-Apr. PMID 16728330
    3. Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. Dohn TE, et al. PLoS Genet, 2019 Feb. PMID 30721228, Free PMC Article
    4. Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms. Duong TB, et al. Dev Biol, 2018 Feb 1. PMID 29157563, Free PMC Article
    5. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Kartopawiro J, et al. Hum Mol Genet, 2014 Mar 1. PMID 24163130

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear receptor subfamily 2 group F member 6a
    Names
    EAR2-A
    chicken ovalbumin upstream promoter transcription factor 2
    nuclear receptor subfamily 2, group F, member 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205557.1 → NP_991120.1  nuclear receptor subfamily 2 group F member 6a

      See identical proteins and their annotated locations for NP_991120.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065330
      UniProtKB/TrEMBL
      A0A8M9Q528, Q6P117
      Related
      ENSDARP00000009513.7, ENSDART00000022379.9
      Conserved Domains (2) summary
      cd06948
      Location:158 → 401
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:53 → 125
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24374325..24386382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478933.2 → XP_021334608.1  nuclear receptor subfamily 2 group F member 6a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q528, Q6P117
      Conserved Domains (2) summary
      cd06948
      Location:158 → 401
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:53 → 125
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

    2. XM_005171225.5 → XP_005171282.1  nuclear receptor subfamily 2 group F member 6a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BIJ5
      Conserved Domains (2) summary
      cd06948
      Location:157 → 400
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:53 → 125
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools