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    pcbp4 poly(rC) binding protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 406391, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pcbp4provided by ZNC
    Official Full Name
    poly(rC) binding protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2122
    See related
    Ensembl:ENSDARG00000024276 AllianceGenome:ZFIN:ZDB-GENE-040426-2122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:65870; zgc:77347; wu:fc68f03
    Summary
    Predicted to enable RNA binding activity. Is expressed in nervous system; otic vesicle; pleuroperitoneal region; somite; and tail bud. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pcbp4 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (32289566..32507975, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (32334942..32553578, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene dystroglycan 1 Neighboring gene nicolin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of pcbp gene family members during zebrafish embryogenesis. Wang J, et al. Gene Expr Patterns, 2020 Jan. PMID 32007595
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213117.2 → NP_998282.2  poly(rC)-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      AL954840, CU469461, CU856621
      UniProtKB/TrEMBL
      F6NN80, Q6NZV5, Q7SZN9
      Related
      ENSDARP00000095464.5, ENSDART00000104693.5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      32289566..32507975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353109.3 → XP_017208598.1  poly(rC)-binding protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z422, F6NN80, Q6NZV5, Q7SZN9

    2. XM_017353108.3 → XP_017208597.1  poly(rC)-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YX89, F6NN80, Q6NZV5, Q7SZN9

    3. XM_009296477.4 → XP_009294752.1  poly(rC)-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B5R6, F6NN80, Q6NZV5, Q7SZN9
      Conserved Domains (2) summary
      cd00105
      Location:280 → 342
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:112 → 176
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    4. XM_009296478.4 → XP_009294753.1  poly(rC)-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AN85
      Conserved Domains (2) summary
      cd00105
      Location:281 → 343
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:112 → 176
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395122.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      63699..90324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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