edn1 endothelin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: edn1provided by ZNC
Official Full Name: endothelin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000920-1
See related: Ensembl:ENSDARG00000036912 AllianceGenome:ZFIN:ZDB-GENE-000920-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: et-1; fb14d01; wu:fb14d01
Summary: Predicted to enable endothelin A receptor binding activity; endothelin B receptor binding activity; and hormone activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell differentiation; and positive regulation of protein secretion. Acts upstream of or within several processes, including anterior lateral line neuromast development; face morphogenesis; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (3376430..3381402, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (3435532..3440504, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phylogenetic analysis of conserved grhl-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 target gene, and this was confirmed by chromatin precipitation assays in embryos.
Title: Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Title: Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway.
Data suggest that edn1/ednraa (endothelin-1/endothelin-1 receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
Title: Endothelin-1 regulates H⁺-ATPase-dependent transepithelial H⁺ secretion in zebrafish.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Title: edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
Title: Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton.
Development of lamprey mucocartilage and its dorsal-ventral patterning by endothelin signaling, with insight into vertebrate jaw evolution.
Title: Development of lamprey mucocartilage and its dorsal-ventral patterning by endothelin signaling, with insight into vertebrate jaw evolution.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
Title: Melanopsin and clock genes: regulation by light and endothelin in the zebrafish ZEM-2S cell line.
activation of Endothelin-1 signaling in craniofacial patterning
Title: Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning.
Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
Title: Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endothelin A receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by endothelin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vein smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endothelin-1

Names: et1; suc; sucker

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.