U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ctsk cathepsin K [ Danio rerio (zebrafish) ]

    Gene ID: 550475, updated on 27-Dec-2024

    Summary

    Official Symbol
    ctskprovided by ZNC
    Official Full Name
    cathepsin Kprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001205-4
    See related
    Ensembl:ENSDARG00000040251 AllianceGenome:ZFIN:ZDB-GENE-001205-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa95f03; wu:fb08b05; zgc:110367
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within bone morphogenesis; cartilage development; and response to mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; fin; head; lateral line system; and mesoderm. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ctsk in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29492994..29502549)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29558371..29567926)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-113g11.6 Neighboring gene uncharacterized LOC137487914 Neighboring gene leucine rich repeat and Ig domain containing 4b Neighboring gene cathepsin S, ortholog2, tandem duplicate 1 Neighboring gene cathepsin S, ortholog 2, tandem duplicate 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type peptidase activity  
    enables hydrolase activity  
    enables peptidase activity  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    is_active_in lysosome  
    located_in plasma membrane  

    General protein information

    Preferred Names
    cathepsin K
    Names
    etID33526.16
    NP_001017778.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017778.1 → NP_001017778.1  cathepsin K precursor

      See identical proteins and their annotated locations for NP_001017778.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092901
      UniProtKB/TrEMBL
      Q568D6
      Related
      ENSDARP00000007535.7, ENSDART00000011497.8
      Conserved Domains (2) summary
      smart00848
      Location:30 → 89
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:118 → 332
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29492994..29502549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.