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    cyth1b cytohesin 1b [ Danio rerio (zebrafish) ]

    Gene ID: 325586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyth1bprovided by ZNC
    Official Full Name
    cytohesin 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4311
    See related
    Ensembl:ENSDARG00000021488 AllianceGenome:ZFIN:ZDB-GENE-030131-4311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc89h04; zgc:73134; wu:fc89h04
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second. Is expressed in blastoderm; intermediate cell mass of mesoderm; neural crest; and polster. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cyth1b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (34051854..34192965)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (33972865..34091980)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene TIMP metallopeptidase inhibitor 2a Neighboring gene uncharacterized LOC137496773 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene uncharacterized LOC108191731 Neighboring gene uncharacterized LOC137496827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress. West JJ, et al. Curr Biol, 2017 Aug 7. PMID 28736167
    2. SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. See K, et al. Hum Mol Genet, 2014 Apr 1. PMID 24218366
    3. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytohesin-1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199722.1 → NP_956016.1  cytohesin-1b

      See identical proteins and their annotated locations for NP_956016.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059497
      UniProtKB/TrEMBL
      A0A8M6Z3G1, Q6PC26
      Related
      ENSDARP00000029832.6, ENSDART00000032821.9
      Conserved Domains (4) summary
      cd01252
      Location:261 → 380
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam00169
      Location:265 → 378
      PH; PH domain
      pfam01369
      Location:64 → 246
      Sec7; Sec7 domain
      pfam15784
      Location:11 → 73
      GPS2_interact; G-protein pathway suppressor 2-interacting domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      34051854..34192965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224522.1 → XP_068080623.1  cytohesin-1b isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z1X0
      Related
      ENSDARP00000157215.1, ENSDART00000180969.1

    2. XM_005169466.5 → XP_005169523.1  cytohesin-1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHC1, A0A8M6Z3G1
      Conserved Domains (4) summary
      cd01252
      Location:278 → 397
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam00169
      Location:282 → 395
      PH; PH domain
      pfam01369
      Location:81 → 263
      Sec7; Sec7 domain
      pfam15784
      Location:18 → 90
      GPS2_interact; G-protein pathway suppressor 2-interacting domain

    3. XM_068224523.1 → XP_068080624.1  cytohesin-1b isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z1X0

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394856.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      253761..297369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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