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    zfhx2 zinc finger homeobox 2 [ Danio rerio (zebrafish) ]

    Gene ID: 795005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfhx2provided by ZNC
    Official Full Name
    zinc finger homeobox 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6699
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-6699
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa03a11
    Summary
    Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and metal ion binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Marsili syndrome. Orthologous to human ZFHX2 (zinc finger homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zfhx2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (14578536..14592216, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (14434187..14447928, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene neuroguidin, EIF4E binding protein Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene thiamine triphosphatase Neighboring gene junctophilin 1a Neighboring gene uncharacterized LOC137489223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase. Delvaux D, et al. Biochim Biophys Acta, 2013 Oct. PMID 23707715

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger homeobox protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      14578536..14592216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001335046.9 → XP_001335082.5  zinc finger homeobox protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PYY4
      Conserved Domains (3) summary
      smart00389
      Location:1340 → 1396
      HOX; Homeodomain
      sd00017
      Location:171 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:1039 → 1090
      Homeobox; Homeobox domain

    2. XM_021470296.2 → XP_021325971.1  zinc finger homeobox protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PUD5
      Conserved Domains (2) summary
      smart00389
      Location:1323 → 1379
      HOX; Homeodomain
      pfam00046
      Location:1022 → 1073
      Homeobox; Homeobox domain

    3. XM_068217174.1 → XP_068073275.1  zinc finger homeobox protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PUD5
    Nucleotide Protein Strain
    Heading Accession and Version

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