p4ha1b prolyl 4-hydroxylase, alpha polypeptide I b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: p4ha1bprovided by ZNC
Official Full Name: prolyl 4-hydroxylase, alpha polypeptide I bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4089
See related: Ensembl:ENSDARG00000071082 AllianceGenome:ZFIN:ZDB-GENE-030131-4089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p4ha1; zgc:56058; wu:fc69d06; wu:fi27h11
Summary: Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (20147402..20167127, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (20127566..20147365, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi27h11.x1 (e-PCR)
- UniSTS:197171

fc69d06.x1 (e-PCR)
- UniSTS:188228

fc69d09.y1 (e-PCR)
- UniSTS:194278

G45160 (e-PCR)
- UniSTS:105962

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prolyl 4-hydroxylase subunit alpha-1b

Names: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I

NP_999856.1

EC 1.14.11.2

XP_009291233.1

EC 1.14.11.2

XP_068070400.1

EC 1.14.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214691.1 → NP_999856.1 prolyl 4-hydroxylase subunit alpha-1b precursor

See identical proteins and their annotated locations for NP_999856.1

Status: PROVISIONAL

Source sequence(s)

BC045890

UniProtKB/TrEMBL

A0A8M1PHF8, Q7ZVE9

Related

ENSDARP00000095644.3, ENSDART00000104874.4

Conserved Domains (4) summary

smart00702
Location:347 → 520

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

sd00006
Location:164 → 199

TPR; TPR repeat [structural motif]

pfam08336
Location:24 → 153

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

pfam13432
Location:168 → 238

TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

20147402..20167127 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292958.4 → XP_009291233.1 prolyl 4-hydroxylase subunit alpha-1b isoform X1

UniProtKB/TrEMBL

A0A2R8RN68, A0A8M3AJP6

Related

ENSDARP00000149102.1, ENSDART00000191995.1

Conserved Domains (4) summary

smart00702
Location:347 → 520

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

sd00006
Location:164 → 199

TPR; TPR repeat [structural motif]

pfam08336
Location:24 → 153

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

pfam13432
Location:168 → 238

TPR_16; Tetratricopeptide repeat
XM_068214299.1 → XP_068070400.1 prolyl 4-hydroxylase subunit alpha-1b isoform X2