dlst dihydrolipoamide S-succinyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlstprovided by ZNC
Official Full Name: dihydrolipoamide S-succinyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030326-1
See related: Ensembl:ENSDARG00000014230 AllianceGenome:ZFIN:ZDB-GENE-030326-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb60; wu:fc39d01
Summary: Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Acts upstream of or within several processes, including ATP biosynthetic process; heart contraction; and mitochondrion organization. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (52524452..52553442)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (52438152..52467142)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

heterozygous inactivation of a tricarboxylic acid (TCA) cycle enzyme, dihydrolipoamide S-succinyltransferase (Dlst), significantly delayed tumor onset in zebrafish without detectable effects on fish development
Title: The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dihydrolipoyllysine-residue succinyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydrolipoyllysine-residue succinyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of oxoglutarate dehydrogenase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Names: schneckentempo

NP_958895.1

EC 2.3.1.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201487.1 → NP_958895.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

See identical proteins and their annotated locations for NP_958895.1

Status: PROVISIONAL

Source sequence(s)

BC045500

UniProtKB/TrEMBL

Q7ZVL3

Related

ENSDARP00000006973.6, ENSDART00000016614.7

Conserved Domains (3) summary

cd06849
Location:71 → 143

lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...

TIGR01347
Location:71 → 457

sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)

pfam00198
Location:243 → 456

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)