wdr43 WD repeat domain 43 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr43provided by ZNC
Official Full Name: WD repeat domain 43provided by ZNC
Primary source: ZFIN:ZDB-GENE-021231-3
See related: Ensembl:ENSDARG00000077264 AllianceGenome:ZFIN:ZDB-GENE-021231-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr43l; chunp6935; kiaa0007l; wu:fb83h12; wu:fc13e01; zgc:110501
Summary: Acts upstream of or within several processes, including blood vessel morphogenesis; embryonic viscerocranium morphogenesis; and hematopoietic stem cell differentiation. Predicted to be active in nucleolus. Is expressed in brain; gut epithelium; and pharyngeal arch. Orthologous to human WDR43 (WD repeat domain 43). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (24821609..24835681)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (24803208..24817280)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrate that Wdr43 functions in ribosome biogenesis, and that defects observed in fan mutants are mediated by a p53 dependent pathway.
Title: Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc27f04.x1 (e-PCR)
- UniSTS:193365

fc13e01.x1 (e-PCR)
- UniSTS:192633

AI584311 (e-PCR)
- UniSTS:206249

fc27f04.x1 (e-PCR)
- UniSTS:187884

fb83h12.x1 (e-PCR)
- UniSTS:191734

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 43

Names: WD repeat domain 43, like; un-named hi821a; unm hi821a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018166.1 → NP_001018176.1 WD repeat-containing protein 43

See identical proteins and their annotated locations for NP_001018176.1

Status: PROVISIONAL

Source sequence(s)

BC095298

UniProtKB/TrEMBL

Q8JHG6

Related

ENSDARP00000124457.1, ENSDART00000112389.3

Conserved Domains (5) summary

COG2319
Location:12 → 271

WD40; WD40 repeat [General function prediction only]

pfam03985
Location:598 → 650

Paf1; Paf1

pfam04003
Location:457 → 558

Utp12; Dip2/Utp12 Family

sd00039
Location:12 → 49

7WD40; WD40 repeat [structural motif]

cl02567
Location:12 → 271

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...