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    acadvl acyl-CoA dehydrogenase very long chain [ Danio rerio (zebrafish) ]

    Gene ID: 573723, updated on 4-Jan-2025

    Summary

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    Official Symbol
    acadvlprovided by ZNC
    Official Full Name
    acyl-CoA dehydrogenase very long chainprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-899
    See related
    Ensembl:ENSDARG00000016687 AllianceGenome:ZFIN:ZDB-GENE-030131-899
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb52d04; zgc:64067; wu:fb52d04; wu:fc75e01
    Summary
    Predicted to enable fatty-acyl-CoA binding activity and very-long-chain fatty acyl-CoA dehydrogenase activity. Acts upstream of or within head development. Predicted to be located in mitochondrial inner membrane. Is expressed in female organism; pectoral fin musculature; and pronephric duct. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See acadvl in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (20298396..20333123)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (20046469..20080639)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch73-335l21.2 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene zgc:194312 Neighboring gene plac8 onzin related protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Carvalho CM, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439725, Free PMC Article
    2. Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Wang Y, et al. Environ Pollut, 2017 Oct. PMID 28601015
    3. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Liu Y, et al. Aquat Toxicol, 2008 Sep 29. PMID 18760846
    4. DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Ding Q, et al. Front Nutr, 2021. PMID 35145984, Free PMC Article
    5. Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. Tian J, et al. Cells, 2022 Jun 9. PMID 35740999, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64067, MGC174519

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within head development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    acyl-Coenzyme A dehydrogenase, very long chain
    vlcad
    NP_997776.1
    XP_068078474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212611.1 → NP_997776.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_997776.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054606
      UniProtKB/TrEMBL
      Q7T2C2
      Related
      ENSDARP00000007240.7, ENSDART00000023089.9
      Conserved Domains (2) summary
      cd01161
      Location:77 → 486
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:107 → 478
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      20298396..20333123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222373.1 → XP_068078474.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

      Related
      ENSDARP00000112163.1, ENSDART00000131019.3
    Nucleotide Protein Strain
    Heading Accession and Version

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