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    tfcp2 transcription factor CP2 [ Danio rerio (zebrafish) ]

    Gene ID: 100001906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tfcp2provided by ZNC
    Official Full Name
    transcription factor CP2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2523
    See related
    Ensembl:ENSDARG00000060306 AllianceGenome:ZFIN:ZDB-GENE-030131-2523
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc10e04; wu:fc10e04; si:ch211-210c8.8
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tfcp2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (33657005..33680265, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (33730474..33753751, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489140 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene POU class 6 homeobox 1 Neighboring gene DAZ associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner. Janicke M, et al. Int J Dev Biol, 2010. PMID 19757382, Free PMC Article
    2. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-globin transcription factor CP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      33657005..33680265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353731.3 → XP_017209220.1  alpha-globin transcription factor CP2 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YW24

    2. XM_005162355.5 → XP_005162412.1  alpha-globin transcription factor CP2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B984
      Conserved Domains (2) summary
      cd09589
      Location:343 → 409
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:57 → 257
      CP2; CP2 transcription factor

    3. XM_001336446.7 → XP_001336482.2  alpha-globin transcription factor CP2 isoform X3

      UniProtKB/TrEMBL
      A0A8M1Q1I0
      Conserved Domains (2) summary
      cd09589
      Location:331 → 397
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:57 → 257
      CP2; CP2 transcription factor

    4. XM_005162354.5 → XP_005162411.1  alpha-globin transcription factor CP2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9A0, E7EYC1
      Related
      ENSDARP00000121618.1, ENSDART00000138416.2
      Conserved Domains (2) summary
      cd09589
      Location:345 → 411
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:57 → 257
      CP2; CP2 transcription factor
    Nucleotide Protein Strain
    Heading Accession and Version

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