jak1 Janus kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jak1provided by ZNC
Official Full Name: Janus kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-142
See related: Ensembl:ENSDARG00000020625 AllianceGenome:ZFIN:ZDB-GENE-980526-142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb93e10; wu:fb93e10
Summary: Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within T cell differentiation in thymus. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytosol. Is expressed in cranial ganglion; otic vesicle; somite; and vasculature. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (31368071..31426386)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (31381157..31439472)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JAK1 activating mutants are insufficient to drive hepatocellular carcinoma development in vivo.
Title: Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish.
Required for cell migration of anterior mesendoderm during gastrulation, resulting in extension of the anterior body axis. MO/dominant negative expression gives identical morphotype/phenotype to STAT3alpha knockdown.
Title: STAT3-dependent pathfinding and control of axonal branching and target selection.
Required for cell migration of anterior mesendoderm during gastrulation, resulting in extension of the anterior body axis. MO/dominant negative expression gives identical morphotype/phenotype to STAT3alpha knockdown.
Title: Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

jak1 (e-PCR), detects polymorphism
- UniSTS:205332

G47536 (e-PCR)
- UniSTS:108310

fe13f04.y1 (e-PCR)
- UniSTS:196157

fc12f09.x1 (e-PCR)
- UniSTS:192591

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK1

Names: etID309794.6; jak-1; jak1 kinase

NP_571148.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131073.1 → NP_571148.1 tyrosine-protein kinase JAK1

See identical proteins and their annotated locations for NP_571148.1

Status: PROVISIONAL

Source sequence(s)

BC047165

UniProtKB/Swiss-Prot

O12990, O73880

UniProtKB/TrEMBL

Q7ZU16

Related

ENSDARP00000037399.7, ENSDART00000038990.8

Conserved Domains (6) summary

cd10378
Location:422 → 523

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:35 → 276

B41; Band 4.1 homologues

cd05077
Location:580 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:280 → 422

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:872 → 1146

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:867 → 1150

PKc_like; Protein Kinases, catalytic domain