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    tprb translocated promoter region b, nuclear basket protein [ Danio rerio (zebrafish) ]

    Gene ID: 558883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tprbprovided by ZNC
    Official Full Name
    translocated promoter region b, nuclear basket proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6410
    See related
    Ensembl:ENSDARG00000016630 AllianceGenome:ZFIN:ZDB-GENE-030131-6410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tpr; wu:fi76g05; si:dkey-97o5.5
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in mRNA export from nucleus and regulation of mitotic spindle assembly. Predicted to act upstream of or within protein import into nucleus. Predicted to be part of nuclear pore. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tprb in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34039281..34069938, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34136402..34167075, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene fignl1 interacting regulator of recombination and mitosis Neighboring gene SCY1-like, kinase-like 3 Neighboring gene proteoglycan 4b Neighboring gene phosducin b Neighboring gene prostaglandin-endoperoxide synthase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Shen W, et al. Cell, 2022 Dec 22. PMID 36493774
    2. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Wu S, et al. Front Cell Dev Biol, 2021. PMID 34722501, Free PMC Article
    3. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
    4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translocated promoter region b, nuclear basket protein
    Names
    translocated promoter region (to activated MET oncogene)
    translocated promoter region b (to activated MET oncogene)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030123.1 → NP_001025294.1  translocated promoter region b, nuclear basket protein

      Status: PROVISIONAL

      Source sequence(s)
      BX323056
      UniProtKB/TrEMBL
      A0A8M1N766, Q5RI09
      Related
      ENSDARP00000019846.7, ENSDART00000017941.9
      Conserved Domains (5) summary
      COG1340
      Location:72 → 355
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      TIGR02168
      Location:221 → 1049
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04420
      Location:1516 → 1569
      CHD5; CHD5-like protein
      pfam07926
      Location:1040 → 1168
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl14813
      Location:230 → 348
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      34039281..34069938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294751.4 → XP_009293026.1  translocated promoter region b, nuclear basket protein isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATA7
      Conserved Domains (5) summary
      COG1340
      Location:72 → 355
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      TIGR02168
      Location:221 → 1049
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04420
      Location:1516 → 1569
      CHD5; CHD5-like protein
      pfam07926
      Location:1040 → 1168
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl14813
      Location:230 → 348
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein Strain
    Heading Accession and Version

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