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    sp4 sp4 transcription factor [ Danio rerio (zebrafish) ]

    Gene ID: 387291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sp4provided by ZNC
    Official Full Name
    sp4 transcription factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031202-3
    See related
    Ensembl:ENSDARG00000005186 AllianceGenome:ZFIN:ZDB-GENE-031202-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64226
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sp4 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (2547215..2560647)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (2616331..2632442)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 196 Neighboring gene uncharacterized LOC103909188 Neighboring gene uncharacterized LOC103909189 Neighboring gene cell division cycle associated 7b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. Zhao J, et al. EMBO J, 2003 Nov 17. PMID 14609954, Free PMC Article
    2. Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio). Varela M, et al. Dev Comp Immunol, 2012 May. PMID 22107841
    3. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Veldman MB, et al. Mol Cell Neurosci, 2010 Apr. PMID 20123021, Free PMC Article
    4. Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Mathieu J, et al. Development, 2004 Feb. PMID 14711879
    5. HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Fu JL, et al. Proc Natl Acad Sci U S A, 2023 Aug. PMID 37487085, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200124.1 → NP_956418.1  transcription factor Sp4

      See identical proteins and their annotated locations for NP_956418.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053313
      UniProtKB/TrEMBL
      Q7T300
      Related
      ENSDARP00000088299.5, ENSDART00000097528.6
      Conserved Domains (4) summary
      COG5048
      Location:566 → 656
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:578 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:636 → 658
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:622 → 645
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      2547215..2560647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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