s1pr1 sphingosine-1-phosphate receptor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: s1pr1provided by ZNC
Official Full Name: sphingosine-1-phosphate receptor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-001228-2
See related: Ensembl:ENSDARG00000042690 AllianceGenome:ZFIN:ZDB-GENE-001228-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: edg1; s1p1; wu:fb98f05; etID43307.22
Summary: Enables lysophosphatidic acid receptor activity. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; mesodermal cell migration; and negative regulation of angiogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; fin bud; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16038488..16042243, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16012218..16015973, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor.
Title: Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor.
Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.
Title: Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Individual s1prs showed unique expression patterns with some overlapping expression domains during early embryogenesis.
Title: Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning
Title: Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
Report role for S1PR1 in regulation venous endothelial barrier function.
Title: Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid receptor activity	IDA Inferred from Direct Assay more info
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 1

Names: S1P receptor 1; S1P receptor Edg-1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131691.3 → NP_571766.3 sphingosine 1-phosphate receptor 1

Status: VALIDATED

Source sequence(s)

BX908392, EH440149, EH598427

UniProtKB/Swiss-Prot

Q6DI49, Q9DDK4

UniProtKB/TrEMBL

Q1LV63

Related

ENSDARP00000062632.3, ENSDART00000062633.4

Conserved Domains (2) summary

pfam00001
Location:41 → 292

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:35 → 307

7tm_4; Olfactory receptor