rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rev3lprovided by ZNC
Official Full Name: REV3 like, DNA directed polymerase zeta catalytic subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050302-55
See related: Ensembl:ENSDARG00000058801 AllianceGenome:ZFIN:ZDB-GENE-050302-55
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7037179; wu:fb98b12; wu:fu65g10
Summary: Predicted to enable several functions, including DNA-directed DNA polymerase activity; iron-sulfur cluster binding activity; and metal ion binding activity. Predicted to act upstream of or within translesion synthesis. Predicted to be located in nuclear lumen. Predicted to be part of zeta DNA polymerase complex. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (3346244..3402639, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (3328743..3385396, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb98b12.x1 (e-PCR)
- UniSTS:203608

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translesion synthesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear lumen	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of zeta DNA polymerase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA polymerase zeta catalytic subunit

Names: REV3-like, catalytic subunit of DNA polymerase zeta; REV3-like, polymerase (DNA directed), zeta, catalytic subunit

XP_021324264.1

EC 2.7.7.7

XP_068071713.1

EC 2.7.7.7

XP_068071714.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

3346244..3402639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215613.1 → XP_068071714.1 DNA polymerase zeta catalytic subunit isoform X2

UniProtKB/TrEMBL

A0A8M1RHW3
XM_068215612.1 → XP_068071713.1 DNA polymerase zeta catalytic subunit isoform X1

Related

ENSDARP00000086696.5, ENSDART00000092264.6
XM_021468589.2 → XP_021324264.1 DNA polymerase zeta catalytic subunit isoform X3

UniProtKB/TrEMBL

A0A8M9PHQ8

Related

ENSDARP00000122052.2, ENSDART00000136987.4

Conserved Domains (4) summary

cd05778
Location:1806 → 2040

DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase

cd05534
Location:2067 → 2515

POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...

pfam14260
Location:2554 → 2621

zf-C4pol; C4-type zinc-finger of DNA polymerase delta

pfam15735
Location:400 → 789

DUF4683; Domain of unknown function (DUF4683)