yod1 YOD1 deubiquitinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: yod1provided by ZNC
Official Full Name: YOD1 deubiquitinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-217
See related: Ensembl:ENSDARG00000008542 AllianceGenome:ZFIN:ZDB-GENE-050417-217
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fe01a10; wu:fe01a10; zgc:112182
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including ERAD pathway; endoplasmic reticulum unfolded protein response; and protein deubiquitination. Predicted to act upstream of or within proteolysis and response to unfolded protein. Predicted to be located in cytoplasm. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (37711022..37719988, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (37443817..37452783, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fe01a10.x1 (e-PCR)
- UniSTS:195898

AW165072 (e-PCR)
- UniSTS:205886

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K11-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K27-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K29-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K33-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin thioesterase OTU1

Names: YOD1 OTU deubiquinating enzyme 1 homolog

NP_001017716.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017716.2 → NP_001017716.1 ubiquitin thioesterase OTU1

See identical proteins and their annotated locations for NP_001017716.1

Status: PROVISIONAL

Source sequence(s)

BC093247

UniProtKB/Swiss-Prot

Q567B1

Related

ENSDARP00000003565.6, ENSDART00000023388.8

Conserved Domains (3) summary

cd01769
Location:5 → 75

UBL; Ubiquitin-like domain of UBL

COG5539
Location:26 → 300

COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]

cl19932
Location:108 → 223

OTU; OTU-like cysteine protease