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    fkbp1aa FKBP prolyl isomerase 1Aa [ Danio rerio (zebrafish) ]

    Gene ID: 335335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkbp1aaprovided by ZNC
    Official Full Name
    FKBP prolyl isomerase 1Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7275
    See related
    Ensembl:ENSDARG00000022684 AllianceGenome:ZFIN:ZDB-GENE-030131-7275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj02g10; zgc:73373; wu:fj02g10
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be active in sarcoplasmic reticulum membrane. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fkbp1aa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49169768..49172500, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49180999..49183731, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene RAD21 cohesin complex component like 1 Neighboring gene syntaphilin Neighboring gene major facilitator superfamily domain containing 2a-like 2 Neighboring gene family with sequence similarity 110 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Holland EB, et al. Aquat Toxicol, 2017 Nov. PMID 28942070, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FKBP prolyl isomerase 1Aa
    Names
    FK506 binding protein 1Aa
    NP_001315489.1
    NP_001315490.1
    NP_956239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328560.1 → NP_001315489.1  FKBP prolyl isomerase 1Aa

      Status: VALIDATED

      Source sequence(s)
      CT737131, EH464309, EH538724
      UniProtKB/TrEMBL
      A0A8M1PG49, Q6PBJ8
      Related
      ENSDARP00000123671.1, ENSDART00000134269.3
      Conserved Domains (1) summary
      COG0545
      Location:2 → 106
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001328561.1 → NP_001315490.1  FKBP prolyl isomerase 1Aa

      Status: VALIDATED

      Source sequence(s)
      CT737131, EH464309, EH538724
      UniProtKB/TrEMBL
      A0A8M1PG49, Q6PBJ8
      Related
      ENSDARP00000119718.1, ENSDART00000142437.2
      Conserved Domains (1) summary
      COG0545
      Location:2 → 106
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

    3. NM_199945.2 → NP_956239.1  FKBP prolyl isomerase 1Aa

      See identical proteins and their annotated locations for NP_956239.1

      Status: VALIDATED

      Source sequence(s)
      CT737131, EH446162, EH464309, EH538724
      UniProtKB/TrEMBL
      A0A8M1PG49, Q6PBJ8
      Related
      ENSDARP00000036607.5, ENSDART00000036157.7
      Conserved Domains (1) summary
      COG0545
      Location:2 → 106
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      49169768..49172500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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