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    wdr3 WD repeat domain 3 [ Danio rerio (zebrafish) ]

    Gene ID: 321058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr3provided by ZNC
    Official Full Name
    WD repeat domain 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9830
    See related
    Ensembl:ENSDARG00000011079 AllianceGenome:ZFIN:ZDB-GENE-030131-9830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb42; wu:fb92b07
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and retina. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human WDR3 (WD repeat domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wdr3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (20853908..20872565)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21043039..21061696)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5C Neighboring gene ganglioside induced differentiation associated protein 2 Neighboring gene uncharacterized LOC137496517 Neighboring gene T-box transcription factor 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model. Shao T, et al. Front Immunol, 2018. PMID 29904386, Free PMC Article
    2. Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Chakraborty A, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29225165
    3. Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO(4)-induced inflammation in zebrafish by metabolomic and proteomic analyses. Gong L, et al. J Neuroinflammation, 2020 Jun 3. PMID 32493433, Free PMC Article
    4. The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Huang G, et al. Autophagy, 2016 Aug 2. PMID 27171500, Free PMC Article
    5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198873.1 → NP_942574.1  WD repeat-containing protein 3

      See identical proteins and their annotated locations for NP_942574.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057490
      UniProtKB/TrEMBL
      Q6PFM8
      Related
      ENSDARP00000023281.8, ENSDART00000003648.10
      Conserved Domains (5) summary
      COG2319
      Location:57 → 692
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:400 → 697
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04003
      Location:799 → 900
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:452 → 487
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:35 → 136
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      20853908..20872565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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