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    slc1a4 solute carrier family 1 member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 368885, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc1a4provided by ZNC
    Official Full Name
    solute carrier family 1 member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-566
    See related
    Ensembl:ENSDARG00000000551 AllianceGenome:ZFIN:ZDB-GENE-030616-566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92817; si:zc101n13.5
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport and L-serine transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; pancreatic system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to human SLC1A4 (solute carrier family 1 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc1a4 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24431213..24447412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24300763..24317250, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene RAB1A, member RAS oncogene family b Neighboring gene centrosomal protein 68 Neighboring gene SERTA domain containing 2b Neighboring gene lectin, galactoside-binding-like b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. Li K, et al. Int J Mol Sci, 2024 Oct 11. PMID 39456733, Free PMC Article
    2. Excitatory amino acid transporters in the zebrafish: Letter to "Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain" from Rico et al. Gesemann M, et al. Brain Res Bull, 2010 Oct 30. PMID 20466040
    3. Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific subfamilies. Gesemann M, et al. BMC Evol Biol, 2010 Apr 29. PMID 20429920, Free PMC Article
    4. Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease. Kim D, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800130, Free PMC Article
    5. mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Scheldeman C, et al. Neurobiol Dis, 2017 Dec. PMID 28888969

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43.
      Title: Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-threonine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neutral amino acid transporter A
    Names
    solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002513.2 → NP_001002513.2  neutral amino acid transporter A

      Status: PROVISIONAL

      Source sequence(s)
      AL772154
      UniProtKB/TrEMBL
      A0A8M1N0N2, Q7ZZ28
      Related
      ENSDARP00000043003.6, ENSDART00000043004.7
      Conserved Domains (1) summary
      pfam00375
      Location:43 → 449
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24431213..24447412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156786.4 → XP_005156843.1  neutral amino acid transporter A isoform X1

      See identical proteins and their annotated locations for XP_005156843.1

      UniProtKB/TrEMBL
      A0A8M2B333, D7RVS1
      Related
      ENSDARP00000057583.3, ENSDART00000057584.6
      Conserved Domains (1) summary
      pfam00375
      Location:43 → 471
      SDF; Sodium:dicarboxylate symporter family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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