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    cntn1a contactin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 353150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cntn1aprovided by ZNC
    Official Full Name
    contactin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030427-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030427-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    F3; cntn1
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; brain development; and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in side of membrane. Predicted to be active in axon and plasma membrane. Is expressed in heart; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy. Orthologous to human CNTN1 (contactin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See cntn1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (5109..147882)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (57465..180145)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene calcium-independent phospholipase A2-gamma Neighboring gene uncharacterized LOC137489302 Neighboring gene uncharacterized LOC137489303 Neighboring gene uncharacterized LOC110438374 Neighboring gene uncharacterized LOC108181599 Neighboring gene hepatic triacylglycerol lipase Neighboring gene disintegrin and metalloproteinase domain-containing protein 10-like Neighboring gene PCNA clamp associated factor Neighboring gene neuronal cell adhesion molecule b Neighboring gene ADAM metallopeptidase domain 10b Neighboring gene von Willebrand factor A domain-containing protein 5A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Gimnopoulos D, et al. Mech Dev, 2002 Dec. PMID 14516675
    2. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Takeuchi M, et al. Genes Cells, 2017 Aug. PMID 28639422
    3. Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth. Almeida RG, et al. Curr Biol, 2021 Sep 13. PMID 34270947, Free PMC Article
    4. The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Haenisch C, et al. Mol Cell Neurosci, 2005 Feb. PMID 15691716
    5. Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish. Schweitzer J, et al. Mol Cell Neurosci, 2007 Jun. PMID 17425960

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The complex regulation patterns suggest roles for Cntn1a in myelinating cells and neurons particularly in successful CNS regeneration.
      Title: Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-1a
    Names
    F3/F11/contactin
    neural cell recognition molecule F11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180969.2 → NP_851300.2  contactin-1a precursor

      See identical proteins and their annotated locations for NP_851300.2

      Status: PROVISIONAL

      Source sequence(s)
      CU458969
      UniProtKB/Swiss-Prot
      Q8AXZ4
      UniProtKB/TrEMBL
      A4JYP8
      Conserved Domains (6) summary
      cd04969
      Location:440 → 511
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00060
      Location:825 → 905
      FN3; Fibronectin type 3 domain
      smart00410
      Location:256 → 336
      IG_like; Immunoglobulin like
      cd00063
      Location:627 → 714
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:423 → 511
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:142 → 237
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      5109..147882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8AXZ4.1 GenPept UniProtKB/Swiss-Prot:Q8AXZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.