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    galk2 galactokinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 792268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    galk2provided by ZNC
    Official Full Name
    galactokinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-143
    See related
    Ensembl:ENSDARG00000004059 AllianceGenome:ZFIN:ZDB-GENE-041114-143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb43h07; wu:fb43h07; zgc:101686
    Summary
    Predicted to enable galactokinase activity. Predicted to be involved in galactose metabolic process. Predicted to act upstream of or within carbohydrate phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See galk2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (32390817..32400209)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (31979860..31989252)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909877 Neighboring gene uncharacterized LOC101882990 Neighboring gene ATPase phospholipid transporting 8B4 Neighboring gene sulfide quinone oxidoreductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3. de la Garza G, et al. J Invest Dermatol, 2013 Jan. PMID 22931925, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101686, MGC192908

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosamine kinase
    NP_001007433.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007432.2 → NP_001007433.2  N-acetylgalactosamine kinase

      Status: VALIDATED

      Source sequence(s)
      BX005048, CU372926
      UniProtKB/TrEMBL
      A0A8M1N3C3, E7FDP4
      Related
      ENSDARP00000005687.9, ENSDART00000012600.11
      Conserved Domains (3) summary
      PLN02521
      Location:16 → 453
      PLN02521; galactokinase
      pfam08544
      Location:356 → 428
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:23 → 71
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      32390817..32400209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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