mmp14b matrix metallopeptidase 14b (membrane-inserted) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mmp14bprovided by ZNC
Official Full Name: matrix metallopeptidase 14b (membrane-inserted)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030901-2
See related: Ensembl:ENSDARG00000008388 AllianceGenome:ZFIN:ZDB-GENE-030901-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MT-MMPbeta
Summary: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (38161267..38183641)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (38178825..38201129)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An injury-responsive mmp14b enhancer is required for heart regeneration.
Title: An injury-responsive mmp14b enhancer is required for heart regeneration.
Data indicate Mmp14a-dependent retinal defects lead to microphthalmia; Mmp14b, on the contrary, does not appear to alter retinal neurogenesis.
Title: Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development.
Data suggest that the MT1-MMP-PTK7 axis plays an important role in normal embryogenesis.
Title: The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
Data show that Mmp14 is required for proper cell polarity underlying the directed migration of mesodermal cells during gastrulation, and identify a genetic interaction between mmp14 and non-canonical Wnt signaling.
Title: Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling.
MT-MMPalpha and beta were expressed through at least the first 72 h of development and this expression was targeted to the cell surface
Title: The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intramembranous ossification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect lamellipodium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect lamellipodium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of extracellular matrix assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: matrix metalloproteinase-14b

Names: matrix metalloproteinase 14 (membrane-inserted) beta; matrix metalloproteinase 14b (membrane-inserted); zMT-MMP-beta

NP_919395.1

EC 3.4.24.80

XP_005171367.1

EC 3.4.24.80

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194414.1 → NP_919395.1 matrix metalloproteinase-14b precursor

See identical proteins and their annotated locations for NP_919395.1

Status: PROVISIONAL

Source sequence(s)

AY324197

UniProtKB/TrEMBL

Q7T2J1

Related

ENSDARP00000044263.5, ENSDART00000044264.6

Conserved Domains (5) summary

cd00094
Location:311 → 503

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:111 → 277

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:111 → 277

Peptidase_M10; Matrixin

pfam01471
Location:29 → 81

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:563 → 621

DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

38161267..38183641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171310.5 → XP_005171367.1 matrix metalloproteinase-14b isoform X1

UniProtKB/TrEMBL

A0A8M2BIQ9, B0R0I1

Conserved Domains (5) summary

cd00094
Location:311 → 503

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:111 → 277

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:111 → 277

Peptidase_M10; Matrixin

pfam01471
Location:29 → 81

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:563 → 621

DUF3377; Domain of unknown function (DUF3377)