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    eps8l1a EPS8 signaling adaptor L1a [ Danio rerio (zebrafish) ]

    Gene ID: 503735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eps8l1aprovided by ZNC
    Official Full Name
    EPS8 signaling adaptor L1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050306-14
    See related
    Ensembl:ENSDARG00000057984 AllianceGenome:ZFIN:ZDB-GENE-050306-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eps8l1; zgc:113583
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be active in ruffle membrane. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eps8l1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16513226..16537441, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16363395..16388807, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 12b Neighboring gene myosin-9 Neighboring gene solute carrier family 6 member 16a Neighboring gene uncharacterized LOC137490516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8-like protein 1a
    Names
    eps8 like 1a
    eps8-like1
    eps8-like1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013313.1 → NP_001013331.1  epidermal growth factor receptor kinase substrate 8-like protein 1a

      See identical proteins and their annotated locations for NP_001013331.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090754
      UniProtKB/TrEMBL
      A0A8M3B857, F1RBZ6, Q5CZQ5
      Related
      ENSDARP00000075195.4, ENSDART00000080749.6
      Conserved Domains (2) summary
      cd09540
      Location:428 → 493
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:283 → 336
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      16513226..16537441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299283.4 → XP_009297558.1  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X3

      UniProtKB/TrEMBL
      A0A8M3B0T2, A0A8M3B857, F1RBZ6
      Conserved Domains (2) summary
      cd09540
      Location:415 → 480
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:270 → 323
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

    2. XM_068216831.1 → XP_068072932.1  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M3B857, F1RBZ6

    3. XM_021470513.2 → XP_021326188.2  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M3B857, F1RBZ6

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      151814..177962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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