cxcr3.3 chemokine (C-X-C motif) receptor 3, tandem duplicate 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cxcr3.3provided by ZNC
Official Full Name: chemokine (C-X-C motif) receptor 3, tandem duplicate 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-100922-34
See related: Ensembl:ENSDARG00000070669 AllianceGenome:ZFIN:ZDB-GENE-100922-34
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-269d20.3
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (11834635..11840134)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (11943658..11947497)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144813.1 → NP_001138285.1 C-X-C chemokine receptor type 3.3

See identical proteins and their annotated locations for NP_001138285.1

Status: PROVISIONAL

Source sequence(s)

BX005342

UniProtKB/TrEMBL

B0S588

Related

ENSDARP00000119122.1, ENSDART00000146611.3

Conserved Domains (1) summary

pfam00001
Location:89 → 309

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

11834635..11840134

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173495.5 → XP_005173552.1 C-X-C chemokine receptor type 3.3 isoform X1

UniProtKB/TrEMBL

A0A8M2BKS4

Conserved Domains (1) summary

pfam00001
Location:96 → 315

7tm_1; 7 transmembrane receptor (rhodopsin family)