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    cep70 centrosomal protein 70 [ Danio rerio (zebrafish) ]

    Gene ID: 100136857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cep70provided by ZNC
    Official Full Name
    centrosomal protein 70provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-311
    See related
    Ensembl:ENSDARG00000076965 AllianceGenome:ZFIN:ZDB-GENE-070705-311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-170g11.4
    Summary
    Predicted to enable gamma-tubulin binding activity. Acts upstream of or within cilium assembly and epithelial cilium movement involved in determination of left/right asymmetry. Located in extracellular region. Is expressed in central canal; hair cell; otic vesicle; pronephric duct; and solid lens vesicle. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cep70 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (12603811..12626056, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (12579501..12601279, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488914 Neighboring gene uncharacterized LOC137489012 Neighboring gene metabolism of cobalamin associated Da Neighboring gene adenosine deaminase RNA specific B1a Neighboring gene uncharacterized LOC110438271 Neighboring gene SLX9 ribosome biogenesis factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. Wilkinson CJ, et al. BMC Cell Biol, 2009 Mar 2. PMID 19254375, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cep70 and Cep131 contribute to ciliogenesis in many tissues in the zebrafish embryo.
      Title: Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 70 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114576.1 → NP_001108048.1  centrosomal protein of 70 kDa

      See identical proteins and their annotated locations for NP_001108048.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154450
      UniProtKB/TrEMBL
      A0A8M9PDS2, A8WFT5
      Related
      ENSDARP00000104406.3, ENSDART00000115344.5
      Conserved Domains (2) summary
      PTZ00400
      Location:183 → 325
      PTZ00400; DnaK-type molecular chaperone; Provisional
      pfam15066
      Location:53 → 167
      CAGE1; Cancer-associated gene protein 1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      12603811..12626056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353091.3 → XP_017208580.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z3B7, A0A8M9P470
    Nucleotide Protein
    Heading Accession and Version

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