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    pdgfab platelet-derived growth factor alpha polypeptide b [ Danio rerio (zebrafish) ]

    Gene ID: 767790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdgfabprovided by ZNC
    Official Full Name
    platelet-derived growth factor alpha polypeptide bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-124
    See related
    Ensembl:ENSDARG00000098578 AllianceGenome:ZFIN:ZDB-GENE-060929-124
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc32c12; zgc:153249
    Summary
    Predicted to enable platelet-derived growth factor receptor binding activity. Involved in angiogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pdgfab in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (12925342..12970418, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (12773481..12819035, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 17b Neighboring gene coiled-coil domain containing 137 Neighboring gene protein kinase, cAMP-dependent, regulatory, type I, beta Neighboring gene centriolar coiled-coil protein of 110 kDa-like Neighboring gene dynein axonemal assembly factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis. Mao A, et al. J Genet Genomics, 2019 Dec 20. PMID 31974005
    2. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Eberhart JK, et al. Nat Genet, 2008 Mar. PMID 18264099, Free PMC Article
    3. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Owen N, et al. Genet Med, 2022 May. PMID 35034853, Free PMC Article
    4. Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish. Lovely CB, et al. Development, 2016 Jun 1. PMID 27122171, Free PMC Article
    5. Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. Bloomekatz J, et al. Elife, 2017 Jan 18. PMID 28098558, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153249

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    platelet-derived growth factor alpha polypeptide b
    Names
    platelet derived growth factor alpha b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076757.1 → NP_001070225.1  platelet-derived growth factor alpha polypeptide b precursor

      See identical proteins and their annotated locations for NP_001070225.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124288
      UniProtKB/TrEMBL
      Q08CD2
      Related
      ENSDARP00000140240.1, ENSDART00000158747.2
      Conserved Domains (2) summary
      pfam00341
      Location:105 → 189
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:22 → 104
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      12925342..12970418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163736.5 → XP_005163793.1  platelet-derived growth factor alpha polypeptide b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAV6
      Conserved Domains (2) summary
      pfam00341
      Location:105 → 189
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:22 → 104
      PDGF_N; Platelet-derived growth factor, N terminal region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394521.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      102511..146600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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