dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dbhprovided by ZNC
Official Full Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-990621-3
See related: Ensembl:ENSDARG00000069446 AllianceGenome:ZFIN:ZDB-GENE-990621-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Acts upstream of or within sleep. Predicted to be located in chromaffin granule lumen; chromaffin granule membrane; and transport vesicle membrane. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (10564447..10607118, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (10606209..10648880, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables dopamine beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dopamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in octopamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sleep	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromaffin granule lumen	IEA Inferred from Electronic Annotation more info
located_in chromaffin granule membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dopamine beta-hydroxylase

Names: dopamine beta hydroxylase

NP_001103164.1

EC 1.14.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109694.2 → NP_001103164.1 dopamine beta-hydroxylase

See identical proteins and their annotated locations for NP_001103164.1

Status: PROVISIONAL

Source sequence(s)

BC163055

UniProtKB/TrEMBL

B3DGL8, B3DIA2, F6NWW7

Related

ENSDARP00000091863.3, ENSDART00000101089.4

Conserved Domains (3) summary

pfam01082
Location:209 → 336

Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain

pfam03351
Location:52 → 168

DOMON; DOMON domain

pfam03712
Location:357 → 512

Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain