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    ttn.2 titin, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 317731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttn.2provided by ZNC
    Official Full Name
    titin, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030113-2
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030113-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ttn; ttna; wu:fi04b11; wu:fi20g08; si:dz258d18.1; si:busm1-258d18.1
    Summary
    A structural constituent of muscle. Acts upstream of or within several processes, including heart contraction; myofibril assembly; and striated muscle tissue development. Is active in centriole; cytoplasm; and nucleus. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; somite; and testis. Used to study atrial fibrillation and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ttn.2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    240
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (42894845..43073959, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (43093058..43272164, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 7 Neighboring gene titin, tandem duplicate 1 Neighboring gene coiled-coil domain containing 141 Neighboring gene SEC14 and spectrin domains 1 Neighboring gene uncharacterized LOC137496430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Epitope of titin A-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells. Mikelsaar AV, et al. Cell Div, 2012 Sep 17. PMID 22985877, Free PMC Article
    2. Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin. Costa ML, et al. Mech Dev, 2002 Aug. PMID 12128209
    3. The zebrafish runzel muscular dystrophy is linked to the titin gene. Steffen LS, et al. Dev Biol, 2007 Sep 15. PMID 17678642, Free PMC Article
    4. Two deltaC splice-variants have distinct signaling abilities during somitogenesis and midline patterning. Mara A, et al. Dev Biol, 2008 Jun 1. PMID 18430417, Free PMC Article
    5. Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle. Hanashima A, et al. Gene, 2017 Jan 5. PMID 27725266

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Primary structure of zebrafish connectin in heart and skeletal muscle
      Title: Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle.
    2. The herzschlag mutant produces a truncated ttna protein, lacking the C-terminal rod domain that is proposed to act as a thick filament scaffold, yet muscle patterning is still initiated, with grossly normal thick and thin filament assembly.
      Title: The titin A-band rod domain is dispensable for initial thick filament assembly in zebrafish.
    3. Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin.
      Title: Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin.
    4. ttna isoform, but not ttnb, is required for sarcomere assembly in the heart as well as the subsequent establishment of cardiac contractility.
      Title: Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myofibril assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomerogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomerogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within striated muscle myosin thick filament assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    titin
    Names
    TTN2
    connectin a
    pickwick
    pik
    titin a
    XP_068079593.1
    XP_068079594.1
    XP_068079595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      42894845..43073959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223494.1 → XP_068079595.1  titin isoform X3

      UniProtKB/TrEMBL
      A0A8M9QKG2

    2. XM_068223493.1 → XP_068079594.1  titin isoform X2

      UniProtKB/TrEMBL
      A0A8M9QKG2

    3. XM_068223492.1 → XP_068079593.1  titin isoform X1

      UniProtKB/TrEMBL
      A0A8M9QKG2
    Nucleotide Protein Strain
    Heading Accession and Version

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