reln reelin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: relnprovided by ZNC
Official Full Name: reelinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020822-1
See related: AllianceGenome:ZFIN:ZDB-GENE-020822-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable hydrolase activity; lipoprotein particle receptor binding activity; and metal ion binding activity. Acts upstream of or within cerebellar Purkinje cell layer morphogenesis. Predicted to be located in extracellular region. Is expressed in immature eye and nervous system. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (50855464..50865844, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (50786626..50946004)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the vertebrate visual system, Reelin gradient is important for laminar targeting and for attracting retinal ganglion cell axons.
Title: An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.
Developmental gene expression pattern of reelin, dab1, vldlr, and apoer2 in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.
Title: Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period.

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General gene information

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Markers

Z1201 (e-PCR)
- UniSTS:51986

G46084 (e-PCR)
- UniSTS:106886

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar Purkinje cell layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: reelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001246276.1 → NP_001233205.1 reelin precursor

See identical proteins and their annotated locations for NP_001233205.1

Status: PROVISIONAL

Source sequence(s)

JF693485

UniProtKB/TrEMBL

G1BJ50

Conserved Domains (15) summary

cd10036
Location:202 → 351

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10038
Location:868 → 1035

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1241 → 1413

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10041
Location:1964 → 2136

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2330 → 2486

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10045
Location:709 → 863

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1073 → 1221

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1453 → 1603

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1808 → 1948

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2172 → 2322

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10051
Location:2899 → 3059

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3274 → 3434

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:1611 → 1782

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd08544
Location:50 → 178

Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam07974
Location:2493 → 2515

EGF_2; EGF-like domain