setd6 SET domain containing 6, protein lysine methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: setd6provided by ZNC
Official Full Name: SET domain containing 6, protein lysine methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1067
See related: Ensembl:ENSDARG00000043986 AllianceGenome:ZFIN:ZDB-GENE-030131-1067
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55627; wu:fb58f11
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; peptidyl-lysine monomethylation; and regulation of inflammatory response. Predicted to act upstream of or within peptidyl-lysine methylation. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; anterior neural keel; immature eye; midbrain; and pectoral fin musculature. Orthologous to human SETD6 (SET domain containing 6, protein lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (17349265..17357132, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (17252865..17260732, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb58f11.x1 (e-PCR)
- UniSTS:190822

AI477662 (e-PCR)
- UniSTS:206446

fb58f11 (e-PCR)
- UniSTS:187247

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-lysine methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-lysine monomethylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine monomethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-lysine methyltransferase setd6

Names: SET domain-containing protein 6

NP_955894.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199600.1 → NP_955894.1 N-lysine methyltransferase setd6

See identical proteins and their annotated locations for NP_955894.1

Status: PROVISIONAL

Source sequence(s)

BC044440

UniProtKB/Swiss-Prot

Q803K4

Related

ENSDARP00000064572.4, ENSDART00000064573.5

Conserved Domains (2) summary

pfam00856
Location:226 → 265

SET; SET domain

pfam09273
Location:317 → 449

Rubis-subs-bind; Rubisco LSMT substrate-binding